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perturbation biology

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Architectures for Adaptive Scientific Reasoning Under Uncertainty

Scientific intelligence increasingly depends on systems that reason from interventions rather than merely fit observations. This review synthesizes conceptual foundations from model-based reinforcement learning, active inference, causal inference, information theory, and perturbation biology into a unified architecture-level view of adaptive scientific reasoning under uncertainty.

ASRA for Decision Biology

Adaptive Scientific Reasoning Architecture (ASRA) applied to decision biology: perturbation–response reasoning, world models, and intervention-centric scientific intelligence. Full text available as PDF (versions 1 and 2).